2nd Joint Work Packages 3 & 5 Taxonomy construction and validation Workshop
11 December 2014, Basel, Switzerland
The work packages responsible for ‘taxonomy construction, knowledge modeling, data-/graph-mining and hypotheses generation’ (WP3) and ‘clinical studies for the validation of the mechanism-based taxonomy’ (WP5) plan their interactions.
9th Benelux Bioinformatics Conference
8-9 December 2014, Luxembourg
Martin Hofmann-Apitius will provide a key-note entitled "computational approaches in dementia research" at the 9th Luxembourg Bioinformatics Conference
IMI-2 Call 2
(Deadline 1 December 2014)
'Ebola and other filoviral haemorrhagic fevers'
AETIONOMY at Janssen Pharma
17 November 2014, Beerse, Belgium
Martin Hofmann-Apitius presented an overview on AETIONOMY strategies and technologies at Janssen Pharma on November 17 in Beerse, Belgium. Bart Vannieuwenhuyse and his team at Janssen Pharma are coordinating EMIF-AD, the IMI project aimed at identifying AD biomarkers and using the EMIF-framework for epidemiological studies and patient recruitment. EMIF-AD will be part of the IMI Alzheimer Research Platform, which consists of the three projects EMIF-AD (biomarkers and epidemiological studies); AETIONOMY (disease mechanisms) and EPAD (adaptive prevention trial on AD).
EMIF-AD and AETIONOMY will collaborate intensively; in particular in the areas of data management, semantic data integration, disease modeling and advanced mining strategies for the identification of disease mechanisms.
IMI-2 Call 1
(Deadline 12 November 2014)
'Type 1 Diabetes Mellitus / dry age-related macular degeneration and diabetic retinopathy'
AETIONOMY - Selventa Inc. joint workshop
30 October 2014, Cambridge/MA, USA
Martin Hofmann-Apitius presented aspects of the AETIONOMY disease modelling and mechanism-identification approach at Selventa Inc. in Cambridge/MA on Thursday, October 30 in a joint workshop with colleagues from Selventa (incl. CEO Dr. David deGraaf and Dr. William Hayes, CTO of Selventa), Eric Neumann (VP at Foundation Medicine), Dr. Magali Haas (Founder and CEO of Orion BioNetworks) and Prof. Tim Clark, Director of Bioinformatics, MassGeneral Institute for Neurodegenerative Disease & Co-Director, Data Management and Statistics Core, Massachusetts Alzheimer's Disease Research Center & Assistant Professor of Neurology, Harvard Medical School.
EPAD - GAP alignment meeting
28 and 29 October 2014, Washington, USA
Martin Hofmann-Apitius representing AETIONOMY at a meeting initiated jointly by the US GAP initiative and the IMI EPAD project. EPAD is IMI´s flagship project aimed at setting up a Alzheimer´s Disease prevention trial; AETIONOMY and EPAD will closely collaborate and form - together with the EMIF-AD project the IMI Research Platform on Alzheimer´s Disease. The purpose of the Washington meeting was to align the large AD research initiatives in North America (including Canada and the US) and Europe (with IMI spearheading AD research at large scale in Europe). One major outcome of this meeting is, that there will be a "global cohort" for prevention trials on AD; effectively integrating cohorts in the US, Canada, Europe, Japan and Australia. A joint, shared study protocol will make sure that results generated with prevention trials in these countries will be comparable.
IMI 2 Open Info Day
30 September 2014, Brussels, Belgium
Information on IMI 2’s funding and intellectual property (IP) rules, tips on applying for funding under IMI 2, and workshops/presentations of the IMI 2 Call 1 topics by the project coordinator.
World Alzheimer's Day
21 September 2014, Worldwide
World Alzheimer's Day, September 21st of each year, is a day on which Alzheimer's organizations around the world concentrate their efforts on raising awareness about Alzheimer's and dementia.
AETIONOMY General Assembly,
External Scientifc Adivsory Board, and Steering Committee Meetings.
17-19 September 2014, Biberach, Germany
Strategic Project Board meetings to monitor the project status and future steps.
Global Dementia Legacy Event,
Harnessing the Power of Discoveries – Maximizing Academia-Industry Synergies.
11-12 September 2014, Ottawa, Canada
Aiming to bring together global leaders from industry and academia to identify new and innovative ways to foster investigative approaches and partnership models to address the pressing challenge of dementia.
ISMB/ISCB Conference 2014
13 July 2014, Boston, USA
Co-authors: Prof. Dr. Martin Hofmann-Apitius, Dr. Erfan Younesi
Intelligent Systems for Molecular Biology (ISMB) conference contribution:
Automated information extraction and knowledge acquisition technology (“text mining”) share the potential to possibly reduce manual reading and human curation efforts for the construction of knowledge bases. Particularly in reference to complex, mostly idiopathic diseases like Alzheimer’s disease (AD), automatic recognition of stage specific speculative statements communicating experimental finding can provide a new insights into the directions of disease etiology and progression. However, a systematic gathering of all scientific speculation that exists in a given contect is a non-trivial task and, if done manually, is laborious and time-consuming. This work presents a methodology that demonstrates how using a dictionary of speculative patterns (HypothesisFinder approach) in combination with designed Alzheimer’s disease ontology (ADO) enables the collection, interpretation, curation and discovery for a broad spectrum of knowledge needed for efficient and systematic AD research.
movie of the talk (youtube)
IMI Info Day – IMI 2 Launch event
10 July 2014, Frankfurt/Main
Keynote: Prof. Dr. Martin Hofmann-Apitius
Members of IMI’s States Representatives Group organise national info sessions on IMI 2 throughout July and August. Events took place in several EU member states and include an overview of IMI 2’s funding and intellectual property (IP) rules, tips on applying for funding under IMI 2, and information on the first IMI 2 Call topics.
AETIONOMY-PRECISESADS Joint Taxonomy workshop
13 June 2014, Paris
Members of the IMI projects AETIONOMY and PRECISESADS presented their work plans and identified opportunities for exchange of knowledge and data. A memorandum of understanding will establish the framework for this collaboration.
AETIONOMY Work Packages 3/5 Taxonomy construction and validation workshop
5 June 2014, Frankfurt/Main
The work packages responsible for ‘taxonomy construction, knowledge modelling, data-/graph-mining and hypotheses generation’ (WP3) and ‘clinical studies for the validation of the mechanism-based taxonomy’ (WP5) informed about their project start-up and aligned planned activities.
20 Mar 2014, Venice
Prof. Dr. Martin Hofmann-Apitius,
General Assembly-Presentation: The IMI project AETIONOMY – a taxonomy for AD/PD
OECD Global Dementia Event
28 March 2014, Paris
Prof. Duncan McHale
AETIONOMY Kick Off Meeting
9 - 10 January 2014
UCB Headquarter Brussels
The AETIONOMY Project was launched at the UCB Headquarters at a 2 day meeting with representatives from all consortium partners present together with IMI staff. The event was opened by IMI Chairman, Michel Goldman who gave an overview of what IMI has achieved so far followed by specific presentations of the Call 8 Taxonomy Projects, AETIONOMY and PRECISESADS. The second day of the meeting saw the work packages meeting in their groups and actually starting the work, focusing on planning for the upcoming milestones and deliv